Ask A Genius 1242: Fisetin
Author(s): Rick Rosner and Scott Douglas Jacobsen
Publication (Outlet/Website): Ask A Genius
Publication Date (yyyy/mm/dd): 2025/02/01
Scott Douglas Jacobsen: What can people do to extend their shelf life?
Rick Rosner: I take a lot of fisetin, a senolytic. It helps your body eliminate cells that should have died off because they no longer function. A senolytic kills senescent cells. In many people, Senescent cells hang on, increasing inflammation and using up your body’s resources.
I’ve been taking fisetin for about 70 months, and it’s fairly effective. But one thing you can do is stay informed because new advancements are happening at an accelerating rate. With AI kicking in, even more breakthroughs will emerge.
So, pay attention. Look around and see what’s new. Fisetin itself is a relatively recent discovery, probably made 8 to 10 years ago.
If you can, get an MRI or ultrasound of your abdomen. A lot in your abdomen could be too late if you wait so late. For example, look at your pancreas, kidneys, and everything in that area. Pancreatic cancer doesn’t cause symptoms until it’s stage 4 and likely metastasizes. At that point, it’s usually untreatable.
However, it’s easy to detect issues in your pancreas years before they develop into cancer. The same goes for your kidneys. If you catch kidney issues early, the prognosis is usually good. If you wait for symptoms, it could spread, and you’re in trouble. So, get an MRI or ultrasound, even if you pay for it out of pocket or your insurance doesn’t cover it.
I have good insurance, but I justified it by having weird blood markers due to working out too much. My high creatinine levels make it seem like there’s something wrong with my kidneys, even though there isn’t. The more you work out, the more muscle breakdown you have, which increases creatinine.
Using those markers, I got an ultrasound that led to an MRI, which helped me find potential issues early.
Also, floss. Your mouth is full of bacteria, and since you’re always swallowing saliva, that floods your digestive tract with bacteria, increasing inflammation. Keeping your mouth as clean as possible helps reduce this.
Exercise regularly. If you have a weight problem, consider Ozempic. It’s a relatively discipline-free way to bring your weight back into a healthy range. Plus, it helps your social life or dating prospects.
Those are the big things, as far as I know. Anything you can do to reduce inflammation is critical. Could you read up on it? Some supplements, like curcumin, claim to be anti-inflammatory, and studies have backed them up.
Getting regular sleep also helps reduce inflammation. Knowledgeable people understand that inflammation significantly contributes to aging and many diseases.
So, there you go.
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